General Information

  • ID:  hor004618
  • Uniprot ID:  Q84W98
  • Protein name:  CLAVATA3/ESR (CLE)-related protein 41
  • Gene name:  CLE41
  • Organism:  Arabidopsis thaliana (Mouse-ear cress)
  • Family:  CLV3/ESR signal peptide family
  • Source:  Plant
  • Expression:  [CLE41p]: Mostly expressed in inflorescence and roots, and, to a lower extent, in seedlings, flowers, leaves and siliques. Observed along the vascular strands in cotyledons, leaves and roots, but not in shoot apical meristems (SAM). Restricted to the phlo
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0033612 receptor serine/threonine kinase binding
  • GO BP:  GO:0010067 procambium histogenesis; GO:0010078 maintenance of root meristem identity; GO:0010087 phloem or xylem histogenesis; GO:0010088 phloem development; GO:0010089 xylem development; GO:0010223 secondary shoot formation; GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0051301 cell division; GO:0090506 axillary shoot meristem initiation
  • GO CC:  GO:0005576 extracellular region; GO:0048046 apoplast

Sequence Information

  • Sequence:  IPMTRHQSTSMVAPFKRVLLESSVPASSTMDLRPKASTRRSRTSRRREFGNDAHEVPSGPNPISN
  • Length:  65
  • Propeptide:  MATSNDQTNTKSSHSRTLLLLFIFLSLLLFSSLTIPMTRHQSTSMVAPFKRVLLESSVPASSTMDLRPKASTRRSRTSRRREFGNDAHEVPSGPNPISN
  • Signal peptide:  MATSNDQTNTKSSHSRTLLLLFIFLSLLLFSSLT
  • Modification:  T57 Hydroxyproline;T60 Hydroxyproline
  • Glycosylation:  T60 O-linked (Ara...) hydroxyproline
  • Mutagenesis:  54-54H->R: Compromised interaction with TDR.; 56-56H->R: Compromised interaction with TDR.; 59-59H->R: Compromised interaction with TDR.; 60-60H->R: Compromised interaction with TDR.; 61-61H->R: Compromised interaction with TDR.; 62-62H->R: Compromised in

Activity

  • Function:  Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q84W98-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004618_AF2.pdbhor004618_ESM.pdb

Physical Information

Mass: 837583 Formula: C305H506N102O96S3
Absent amino acids: CWY Common amino acids: S
pI: 12.21 Basic residues: 13
Polar residues: 21 Hydrophobic residues: 15
Hydrophobicity: -84.31 Boman Index: -20539
Half-Life: 20 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 54
Instability Index: 8888.77 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA